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Molecular analysis of primary lung tumor tissue (PT), corresponding circulating tumor cell cluster and three single CTCs. MassARRAY system (iPLEx Lung) shows heterozygous mutation for KRAS G12S in PT. ( A ) Same mutation is seen in the CTC cluster ( B ) and in one single CTC ( C ), whereas two single CTCs ( D , E ) show no mutation for KRAS.

Journal: Scientific Reports

Article Title: EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients

doi: 10.1038/s41598-019-43678-6

Figure Lengend Snippet: Molecular analysis of primary lung tumor tissue (PT), corresponding circulating tumor cell cluster and three single CTCs. MassARRAY system (iPLEx Lung) shows heterozygous mutation for KRAS G12S in PT. ( A ) Same mutation is seen in the CTC cluster ( B ) and in one single CTC ( C ), whereas two single CTCs ( D , E ) show no mutation for KRAS.

Article Snippet: For the targeted detection of somatic mutations in CTCs and tissue we used the iPLEX HS technology in conjunction with the MALDI-TOF based MassARRAY System (Agena Bioscience, San Diego, California).

Techniques: Mutagenesis